Thermodynamic Coupling in Asymmetric Lipid Membranes

Fluid lipid bilayers: Intermonolayer coupling and its thermodynamic manifestations

Asymmetric Lipid Membranes: Towards More Realistic Model Systems

Despite the ubiquity of transbilayer asymmetry in natural cell membranes, the vast majority of existing research has utilized chemically well-defined symmetric liposomes, where the inner and outer bilayer leaflets have the same composition. Here, we review various aspects of asymmetry in nature and in model systems in anticipation for the next phase of model membrane studies.

Calculating the Bending Modulus for Multicomponent Lipid Membranes in Different Thermodynamic Phases

We establish a computational approach to extract the bending modulus, KC , for lipid membranes from relatively small-scale molecular simulations. Fluctuations in the splay of individual pairs of lipids faithfully inform on KC in multicomponent membranes over a large range of rigidities in different thermodynamic phases. Predictions are validated by experiments even where the standard spectral a...

Lipid Properties in Membranes

branes separating two aqeous phases: Formation of a membrane of a single composition," J. Mol. Biol. 8 (1964): 148-160. 38. Ghosh, D., M. A. Williams, and J. Tinoco, "The influence of lecithin structure on their monolayer behavior and interactions with cholesterol," Biochim, Biophys. Acta 291 (1973): 351-362. 39. MacDonald, R. C., and S. A. Simon, "Lipid monolayer states and their relationships...

Lipid Membranes